Busy weekend here in Boston with Father's Day, Juneteenth, and U.S. Open golf. My wife and I went to the tournament on Friday, and we had to travel by car, subway, and shuttle bus to go less than 20 miles. While getting around in Boston is always a challenge, it's not the only place that's difficult to navigate, and therein lies the inspiration for today's puzzle. Now you'll need to be very patient while solving this one, so please keep your "row rage" in check.

I'd like to thank @Abide, @Al Sisti, @whimsy, @MarkWoychick, @boharr, and @Joe Ross for pretesting and technical help, and a special thanks to @MaineMarge for providing the inspiration for the title.
The meta answer is a U.S. town that may be difficult to get to.
You Can't Get There From Here - Crosshare
You Can't Get There From Here - PUZ
You Can't Get There From Here - PDF
You Can't Get There From Here - Spreadsheet

Nudges are here.
Solution is here.
Happy motoring!
Cap'n Rick